Torben Klarl's paper, together with his co-authors David Audretsch and Dirk Fornahl, introduces the special issue of Small Business Economics on "Radical innovation, entrepreneurship and (regional) growth" and presents a roadmap for future research in this area. This article argues that the link between the literature on radical innovation, entrepreneurship, and (regional) growth is still an underresearched topic. This paper also reviews the special issue’s contributions that allow for a more nuanced understanding of this important link.