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Faculty 11 Human and Health Sciences: Clinical psychology and Psychotherapy of adulthood

Obsessive-compulsive disorder

Obsessive-compulsive disorder is characterized by obsessive thoughts and/or compulsions that are highly disruptive and often chronic. For example, people are afraid of contamination or infection and therefore disinfect, wash and clean excessively. In the area of obsessive-compulsive disorder, we are conducting basic research to better understand which processes are altered in obsessive-compulsive disorder (including attentional processes). We are also investigating the effect of new therapeutic interventions and which processes can influence or impair the treatment of obsessive-compulsive disorder. Additionally, we are validating a German translation of a questionnaire on obsessive-compulsive symptoms. 

Current research project:

Attention bias and the role of attentional control in obsessive-compulsive disorder: An eye-tracking study with idiosyncratic material

Funding: DFG

Project participants: Celina Müller (LMU, Munich), Thomas Ehring (LMU, Munich)

Principal investigator: Barbara Cludius (University of Bremen)

Cooperation partners: Benedikt Ehinger (University of Stuttgart)

It is assumed that people with obsessive-compulsive disorder (OCD) look faster and longer at OCD-related stimuli. Previous research on this has revealed mixed results. One reason could be that each individual with experiences very different stimuli as relevant. In this study (https://osf.io/m27hc), we include people with different types of obsessions and compulsions. We show them a variety of pictures and measure their eye movements with an eye tracker. For each person, we only analyze the eye movements for those images that they classify as personally relevant for their OCD. We compare the eye movements with the those of people with spider phobia (clinical control group) and healthy controls to test whether the eye movements are specific to OCD. As the relationship between OCD symptoms and attentional biases may be more complex than previously investigated, we also test the influence of attentional control and stress experience (moderators).

Publications

  1. Claus, N., Miegel, F., Jelinek, L., Landmann, S., Moritz, S., Külz, A. K., Rubel, J., & Cludius, B. (2023). Perfectionism as Possible Predictor for Treatment Success in Mindfulness-Based Cognitive Therapy and Metacognitive Training as Third-Wave Treatments for Obsessive-Compulsive Disorder. Cognitive Therapy and Research. https://doi.org/10.1007/s10608-023-10361-0
  2. Cludius, B., Landmann, S., Külz, A.-K., Takano, K., Moritz, S., & Jelinek, L. (2022). Direct and indirect assessment of perfectionism in patients with depression and obsessive-compulsive disorder. PLOS ONE, 17(10), e0270184. https://doi.org/10.1371/journal.pone.0270184
  3. Miegel, F., Demiralay, C., Sure, A., Moritz, S., Hottenrott, B., Cludius, B., & Jelinek, L. (2022). The Metacognitive Training for obsessive-compulsive disorder: A pilot study. Current Psychology, 41(10), 7114–7124. https://doi.org/10.1007/s12144-020-01158-5
  4. Cludius, B., Mannsfeld, A. K., Schmidt, A. F., & Jelinek, L. (2021). Anger and aggressiveness in obsessive–compulsive disorder (OCD) and the mediating role of responsibility, non-acceptance of emotions, and social desirability. European Archives of Psychiatry and Clinical Neuroscience, 271(6), 1179–1191. https://doi.org/10.1007/s00406-020-01199-8
  5. Schröder, J., Werkle, N., Cludius, B., Jelinek, L., Moritz, S., & Westermann, S. (2020). Unguided Internet‐based cognitive‐behavioral therapy for obsessive‐compulsive disorder: A randomized controlled trial. Depression and Anxiety, 37(12), 1208–1220. https://doi.org/10.1002/da.23105
  6. Miegel, F., Cludius, B., Hottenrott, B., Demiralay, C., Sure, A., & Jelinek, L. (2020). Session-specific effects of the Metacognitive Training for Obsessive-Compulsive Disorder (MCT-OCD). Psychotherapy Research, 30(4), 474–486. https://doi.org/10.1080/10503307.2019.1613582
  7. Cludius, B.*, Landmann, S. *, Rose, N., Heidenreich, T., Hottenrott, B., Schröder, J., Jelinek, L., Voderholzer, U., Külz, A. K., & Moritz, S. (2020). Long-term effects of mindfulness-based cognitive therapy in patients with obsessive-compulsive disorder and residual symptoms after cognitive behavioral therapy: Twelve-month follow-up of a randomized controlled trial. Psychiatry Research, 291, 113119. https://doi.org/10.1016/j.psychres.2020.113119 [*geteilte Erstautorenschaft]
  8. Miegel, F., Moritz, S., Wagener, F., Cludius, B., & Jelinek, L. (2020). Self-esteem mediates the relationship between perfectionism and obsessive-compulsive symptoms. Personality and Individual Differences, 167, 110239. https://doi.org/10.1016/j.paid.2020.110239
  9. Landmann, S., Cludius, B., Tuschen-Caffier, B., Moritz, S., & Külz, A. K. (2020). Changes in the daily life experience of patients with obsessive-compulsive disorder following mindfulness-based cognitive therapy: Looking beyond symptom reduction using ecological momentary assessment. Psychiatry Research, 286, 112842. https://doi.org/10.1016/j.psychres.2020.112842
  10. Landmann, S., Cludius, B., Tuschen-Caffier, B., Moritz, S., & Külz, A. K. (2019). Mindfulness predicts insight in obsessive-compulsive disorder over and above OC symptoms: An experience-sampling study. Behaviour Research and Therapy, 121, 103449. https://doi.org/10.1016/j.brat.2019.103449
  11. Külz, A. K., Landmann, S., Cludius, B., Rose, N., Heidenreich, T., Jelinek, L., Alsleben, H., Wahl, K., Philipsen, A., Voderholzer, U., Maier, J. G., & Moritz, S. (2019). Mindfulness-based cognitive therapy (MBCT) in patients with obsessive–compulsive disorder (OCD) and residual symptoms after cognitive behavioral therapy (CBT): A randomized controlled trial. European Archives of Psychiatry and Clinical Neuroscience, 269(2), 223–233. https://doi.org/10.1007/s00406-018-0957-4
  12. Miegel, F., Cludius, B., Hottenrott, B., Demiralay, C., & Jelinek, L. (2020). Session-specific effects of the Metacognitive Group Training for Obsessive–Compulsive Disorder: Significant results for thought control. Scientific Reports, 10(1), 17816. https://doi.org/10.1038/s41598-020-73122-z
  13. Cludius, B., Wenzlaff, F., Briken, P., & Wittekind, C. E. (2019). Attentional biases of vigilance and maintenance in obsessive-compulsive disorder: An eye-tracking study. Journal of Obsessive-Compulsive and Related Disorders, 20, 30–38. https://doi.org/10.1016/j.jocrd.2017.12.007
  14. Cludius, B., Schmidt, A. F., Moritz, S., Banse, R., & Jelinek, L. (2017). Implicit aggressiveness in patients with obsessive-compulsive disorder as assessed by an Implicit Association Test. Journal of Behavior Therapy and Experimental Psychiatry, 55, 106–112. https://doi.org/10.1016/j.jbtep.2017.01.001
  15. Cludius, B., Hottenrott, B., Alsleben, H., Peter, U., Schröder, J., & Moritz, S. (2015). Mindfulness for OCD? No evidence for a direct effect of a self-help treatment approach. Journal of Obsessive-Compulsive and Related Disorders, 6, 59–65. https://doi.org/10.1016/j.jocrd.2015.05.003
  16. Moritz, S., Fieker, M., Hottenrott, B., Seeralan, T., Cludius, B., Kolbeck, K., Gallinat, J., & Nestoriuc, Y. (2015). No pain, no gain? Adverse effects of psychotherapy in obsessive–compulsive disorder and its relationship to treatment gains. Journal of Obsessive-Compulsive and Related Disorders, 5, 61–66. https://doi.org/10.1016/j.jocrd.2015.02.002
  17. Külz, A. K., Landmann, S., Cludius, B., Hottenrott, B., Rose, N., Heidenreich, T., Hertenstein, E., Voderholzer, U., & Moritz, S. (2014). Mindfulness-based cognitive therapy in obsessive-compulsive disorder: Protocol of a randomized controlled trial. BMC Psychiatry, 14(1), 314. https://doi.org/10.1186/s12888-014-0314-8
Updated by: Nils-Henrik Stöver
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