Repetitive Dosing of Fumed Silica Leads to Profibrogenic Effects through Unique Structure−Activity Relationships and Biopersistence in the Lung
effects. In contrast, the NLRP3 inflammasome pathway was continuously activated by repetitive-dose administration of 3 × 7 mg/kg fumed silica, 1 week apart. We also found that while single-dose exposure failed [...] effects disappeared when less surface-reactive titanium-doped fumed silica was used for recurrent administration. All considered, these data indicate that while fumed silica may be regarded as safe for some